13项全球权威临床试验告诉你，如何科学服用NMN？

250mg-300mg NMN是临床研究中较多采用的剂量，数据显示每日口服100mg NMN、600mg NMN、900mg NMN、2000mg NMN几种剂量均安全。

临床研究显示，服用NMN出现最多的周期为8-12周，最长服用周期为24周，服用人群出现最多的为40-80岁区间 。

参考资料：

[1] Schultz, M. B., & Sinclair, D. A. (2016). Why NAD(+) Declines during Aging: It's Destroyed. Cell metabolism, 23(6), 965–966. https://doi.org/10.1016/j.cmet.2016.05.022

[2] Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature reviews. Molecular cell biology, 22(2), 119–141. https://doi.org/10.1038/s41580-020-00313-x

[3] Okabe, K., Yaku, K., Uchida, Y., Fukamizu, Y., Sato, T., Sakurai, T., Tobe, K., & Nakagawa, T. (2022). Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects. Frontiers innutrition, 9, 868640. https://doi.org/10.3389/fnut.2022.868640  

[4]Irie, J. et al. Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Endocr J 67, 153–160 (2020).

[5]Yoshino, M. et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science 372, 1224–1229 (2021).

[6]Igarashi, M. et al. Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. NPJ Aging 8, 5 (2022).

[7]Liao, B. et al. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: A randomized, double-blind study. J. Int. Soc. Sports Nutr. 18, 54 (2021).

[8]Kim, M. et al. Effect of 12-week intake of nicotinamide mononucleotide on sleep quality, fatigue, and physical performance in older Japanese adults: A randomized, double-blind placebo-controlled study. Nutrients 14, 755 (2022).

[9]Pencina, M. et al. MIB-626, an Oral Formulation of a Microcrystalline Unique Polymorph of β-Nicotinamide Mononucleotide, Increases Circulating Nicotinamide Adenine Dinucleotide and its Metabolome in Middle-Aged and Older Adults. Gerontology 78,1(2023)

[10]Okabe, K. et al. Oral administration of nicotinamide mononucleotide is safe and efficiently increases blood nicotinamide adenine dinucleotide levels in healthy subjects. Front. Nutr. 9, 868640 (2022).

[11]Hao Huang. A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults. Front. Aging. 3,851698(2022).

[12]Morita, J. et al. Clinical evaluation of changes in biomarkers by oral intake of NMN. Glycative Stress Research 9,2(2022)

[13]Yi, L. et al. The efficacy and safety of βnicotinamide mononucleotide (NMN) supplementation in healthy middleaged adults: a randomized, multicenter, doubleblind, placebocontrolled, parallelgroup, dosedependent clinical trial. GeroScience 45,29-43(2023)

[14]Akasaka, H. et al. Effects of nicotinamide mononucleotide on older patients withdiabetes and impaired physical performance: A prospective, placebo-controlled, double-blind study. Geriatr Gerontol Int. 23,1(2023)

[15]Fukamizu, Y. et al. Safety evaluation of βnicotinamide mononucleotide oral administration in healthy adult men and women. Scientific Reports 12: 114442(2022)

[16]Katayoshi, T. et al. Nicotinamide adenine dinucleotide metabolism and arterial stiffness after longterm nicotinamide mononucleotide supplementation: a randomized, doubleblind, placebocontrolled trial. Scientific Reports 13:2786(2023)